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There are 6 seven-letter words containing DESP

DESPAIRdespair v. (Transitive, obsolete) To give up as beyond hope or expectation; to despair of.
despair v. (Transitive) To cause to despair.
despair v. (Intransitive, often with “of”) To be hopeless; to have no hope; to give up all hope or expectation.
DESPISEdespise v. To regard with contempt or scorn.
despise v. To disregard or ignore.
DESPISE v. to look down upon with contempt.
DESPITEdespite prep. In spite of, notwithstanding.
despite n. (Obsolete) Disdain, contemptuous feelings, hatred.
despite n. (Archaic) Action or behaviour displaying such feelings; an outrage, insult.
DESPOILdespoil v. (Transitive) To plunder; to pillage; take spoil from.
despoil v. (Transitive) To violently strip (someone), with indirect object of their possessions etc.; to rob.
despoil v. (Obsolete, transitive or reflexive) To strip (someone) of their clothes; to undress.
DESPONDdespond v. To give up the will, courage, or spirit; to become dejected, lose heart.
despond n. (Archaic) Despondency.
DESPOND v. to lose heart.
DESPOTSdespots n. Plural of despot.
DESPOT n. a ruler with absolute power and authority.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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