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There are 4 six-letter words containing DEFE

DEFEATdefeat v. (Transitive) To overcome in battle or contest.
defeat v. (Transitive) To reduce, to nothing, the strength of.
defeat v. (Transitive) To nullify.
DEFECTdefect n. A fault or malfunction.
defect n. The quantity or amount by which anything falls short.
defect n. (Mathematics) A part by which a figure or quantity is wanting or deficient.
DEFENDdefend v. (Transitive) To ward off attacks against; to fight to protect; to guard.
defend v. (Transitive) To support by words or writing; to vindicate, talk in favour of.
defend v. (Transitive, law) To make legal defence of; to represent (the accused).
DEFERSdefers v. Third-person singular simple present indicative form of defer.
DEFER v. to postpone.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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