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There are 16 fifteen-letter words containing DEST

AUTODESTRUCTINGautodestructing v. Present participle of autodestruct.
AUTODESTRUCT v. to self-destruct.
AUTODESTRUCTIVEautodestructive adj. Self-destroying.
AUTODESTRUCT adj. to self-destruct.
BIODESTRUCTIBLEbiodestructible adj. Capable of being destroyed by natural biological processes.
BIODESTRUCTIBLE adj. biodegradable.
CLANDESTINENESSclandestineness n. The state or quality of being clandestine.
CLANDESTINENESS n. the state of being clandestine.
CLANDESTINITIESclandestinities n. Plural of clandestinity.
CLANDESTINITY n. the quality of being clandestine.
DESTABILISATIONdestabilisation n. Alternative spelling of destabilization.
DESTABILISATION n. the act of destabilising, also DESTABILIZATION.
DESTABILIZATIONdestabilization n. The act or process of destabilizing.
DESTABILIZATION n. the act of destabilizing, also DESTABILISATION.
DESTITUTENESSESDESTITUTENESS n. the state of being destitute.
DESTRUCTIBILITYdestructibility n. The condition of being destructible.
DESTRUCTIBILITY n. the state of being destructible.
DESTRUCTIONISTSdestructionists n. Plural of destructionist.
DESTRUCTIONIST n. one who delights in or advocates destruction.
DESTRUCTIVENESSdestructiveness n. The state or quality of being destructive.
DESTRUCTIVENESS n. the state of being destructive.
DESTRUCTIVITIESdestructivities n. Plural of destructivity.
DESTRUCTIVITY n. capacity for destruction.
PEDESTRIANISINGpedestrianising v. Present participle of pedestrianise.
PEDESTRIANISE v. to make pedestrian, also PEDESTRIANIZE.
PEDESTRIANIZINGpedestrianizing v. Present participle of pedestrianize.
PEDESTRIANIZE v. to make pedestrian, also PEDESTRIANISE.
PREDESTINARIANSpredestinarians n. Plural of predestinarian.
PREDESTINARIAN n. one who believes in predestination.
PREDESTINATIONSpredestinations n. Plural of predestination.
PREDESTINATION n. the act of predestinating.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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