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There are 13 eight-letter words containing COF

COFACTORcofactor n. A contributing factor.
cofactor n. (Biochemistry) A substance, especially a coenzyme or a metal, that must be present for an enzyme to function.
cofactor n. (Biochemistry) A molecule that binds to and regulates the activity of a protein.
COFFEREDcoffered adj. (Architecture) Having coffers.
coffered v. Simple past tense and past participle of coffer.
COFFER v. to put in a strongbox.
COFFINEDcoffined v. Simple past tense and past participle of coffin.
COFFIN v. to put in a burial box.
COFFLINGcoffling v. Present participle of coffle.
COFFLE v. (Arabic) to chain slaves together.
COFFRETScoffrets n. Plural of coffret.
COFFRET n. (French) a small strongbox.
COFIRINGcofiring v. Present participle of cofire.
cofiring n. The combustion of two or more fuels at the same time.
cofiring n. The sintering of two or more materials together.
COFOUNDScofounds v. Third-person singular simple present indicative form of cofound.
co-founds v. Third-person singular simple present indicative form of co-found.
COFOUND v. to found jointly.
ECOFREAKecofreak n. (Informal, derogatory) A person with a passion for protecting the natural environment; an ecological activist.
ECOFREAK n. a zealous environmentalist.
LOCOFOCOlocofoco n. (Archaic) A match (used for making fire).
Locofoco n. (US, politics, historical) A member of a faction of the US Democratic Party in the early 1800s, formed…
LOCOFOCO n. (Spanish) a match or cigar which can be lit by friction on any rough surface.
SCOFFERSscoffers n. Plural of scoffer.
SCOFFER n. one who scoffs.
SCOFFINGscoffing v. Present participle of scoff.
scoffing n. The act of one who scoffs; derision; mockery.
SCOFFING adj. scornful.
SCOFFLAWscofflaw n. (US) One who habitually violates minor laws or fails to answer trivial court summonses (such as parking tickets).
SCOFFLAW n. a habitual law violator.
UNCOFFINuncoffin v. (Transitive, sometimes figurative) To remove from a coffin; to exhume.
UNCOFFIN v. to remove from a coffin.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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