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There are 3 words ending with UPUS

LUPUSlupus n. (Pathology) Any of a number of autoimmune diseases, the most common of which is systemic lupus erythematosus.
Lupus prop.n. (Astronomy) A summer constellation of the southern sky, said to resemble a wolf. It lies south of the…
Lupus prop.n. A city and village in Missouri, United States.
PUPUSPUPU n. (Hawaiian) a dish of Asian foods served as an appetize.
GAUPUSgaupus n. Alternative form of gawpus.
GAUPUS n. (dialect) a silly person, also GAWPUS.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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