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There are 3 four-letter words ending with USE

FUSEfuse n. A cord that, when lit, conveys the fire to some explosive device.
fuse n. (Manufacturing, mining, military) The mechanism that ignites the charge in an explosive device; a detonator.
fuse n. (Figurative) A tendency to lose one’s temper.
MUSEmuse n. A source of inspiration.
muse n. (Archaic) A poet; a bard.
muse v. (Intransitive) To become lost in thought, to ponder.
RUSEruse n. (Countable, often hunting, archaic, rare) A turning or doubling back, especially of animals to get out…
ruse n. (Countable, by extension) An action intended to deceive; a trick.
ruse n. (Uncountable) Cunning, guile, trickery.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org.

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