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There are 2 eight-letter words ending with TOLE

ASYSTOLEasystole n. (Pathology, cardiology) Absence of systole; failure of the heart to contract.
ASYSTOLE n. a heart malfunction.
DIASTOLEdiastole n. (Chiefly uncountable, physiology) The phase or process of relaxation and dilation of the heart chambers…
diastole n. (Uncountable, prosody) The lengthening of a vowel or syllable beyond its typical length.
diastole n. (Greek grammar) The hypodiastole, a textual or punctuation mark formerly used to disambiguate homonyms in Greek.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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