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There are 4 five-letter words ending with SCO

CASCOcasco n. (Nautical) A flat-bottomed, square-ended boat once used in the Philippines as a lighter to ferry goods…
Casco prop.n. A surname.
CASCO n. (Spanish) a Philippine cargo barge.
CISCOcisco n. Any North American freshwater fish of certain species of the genus Coregonus that live in cold-water lakes.
Cisco prop.n. Cisco Systems, Inc., a manufacturer of routers, switches, and other networking and communications equipment.
CISCO n. a North American lake fish.
DISCOdisco n. (Countable, slightly dated) Clipping of discotheque, a nightclub for dancing.
disco n. (Uncountable, music) A genre of dance music that was popular in the 1970s, characterized by elements…
disco v. (Intransitive) To dance disco-style dances.
PISCOpisco n. A liquor distilled from grapes (a brandy) made in wine-producing regions of Peru and Chile. It is the…
Pisco n. A kind of brandy produced in Peru and Chile.
PISCO n. a Peruvian brandy.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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