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There is only one twelve-letter word ending with ITHECIUM

AMPHITHECIUMAMPHITHECIUM n. the outer layer of cells of the embryo of mosses and liverworts that develops into the outer parts of the spore-bearing capsule.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definition is a short excerpt from the 1Word.ws.

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