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There is only one five-letter word ending with IRUS

VIRUSvirus n. A submicroscopic, non-cellular structure consisting of a core of DNA or RNA surrounded by a protein…
virus n. (Uncountable) A quantity of such infectious agents.
virus n. (Informal, metonymically) A disease caused by such an infectious agent; a viral illness.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org.

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