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There are 9 words ending with ISC

DISCdisc n. A thin, flat, circular plate or similar object.
disc n. (Anatomy) An intervertebral disc.
disc n. Something resembling a disc.
FISCfisc n. (Ancient Rome) The public treasury of Rome.
fisc n. Any state treasury or exchequer.
FISC n. (obsolete) the state treasury; the public revenue, also FISK.
PANISCpanisc n. The god Pan, represented as a satyr.
Panisc n. Alternative form of panisc.
PANISC n. (Greek) an inferior god, attendant upon Pan, also PANISK.
LENTISCLENTISC n. the mastic tree, also LENTISK.
MINIDISCminidisc n. A disc/disk in MiniDisc format.
minidisc n. A minidisc player or recorder.
MiniDisc n. (Uncountable) A magnetooptical format for storing digital audio.
LASERDISClaserdisc n. A home videodisc in the Laserdisc format.
Laserdisc prop.n. A home videodisc format of the 1980s, now obsolete.
Laserdisc n. (Countable) A disc in this format.
MULTIDISCmultidisc adj. Composed of multiple discs.
MULTIDISC adj. involving more than one disc.
VIDEODISCvideodisc n. A video recording of visual images and sounds on an optical disc that can be played on a television receiver.
VIDEODISC n. a compact disk on which video is stored, also VIDEODISK.
BLASTODISCblastodisc n. Alternative form of blastodisk.
BLASTODISC n. the embryo-forming portion of an egg with discoid cleavage.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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