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There are 18 three-letter words ending with IS

AISais n. Plural of ai.
Ais prop.n. Plural of Ai.
AIs n. Plural of AI.
BISbis n. Plural of bi.
bis adv. Twice; showing that something is, or is to be, repeated, such as a passage of music, or an item in accounts.
bis sym. (International standards) ISO 639-2 & ISO 639-3 language code for Bislama.
CIScis adj. (Biology) Having two mutations on two genes on the same chromosome of a homologous pair.
cis adj. (Cytology) Of the side of the Golgi apparatus nearer to the endoplasmic reticulum.
cis adj. (Chemistry) In (or constituting, forming, or describing) a double bond in which the greater radical…
DISdis v. (Informal) Alternative spelling of diss.
dis n. Alternative form of diss.
dis n. (Norse mythology) Any of a group of minor female deities in Scandinavian folklore.
GISgis n. (Ornithology, slang) Alternative spelling of jizz.
gis cont. Alternative form of gi’s.
GIs n. Plural of GI.
HIShis det. Belonging to him.
his det. (Sometimes dated) Belonging to a person of unspecified gender.
his det. (Obsolete) Its; belonging to it. (Now only when implying personification.)
KISkis n. Plural of ki.
KI n. (Japanese) the spirit of martial art.
LISlis n. (Heraldry) fleur-de-lis.
lis n. Plural of li.
lis n. (Law) The substance of a legal dispute.
MISmis sym. (International standards) ISO 639-2 & ISO 639-3 language code for unencoded languages.
Mis prop.n. A surname.
MIs n. Plural of MI.
NISnis n. A nix; a hobgoblin.
nis cont. (Obsolete) Contraction of ne is.
NIS adj. (Classified ads) Initialism of new in shrink.
OISOIs n. Plural of OI.
OIS n. (Law enforcement) Initialism of officer-involved shooting.
OIS n. (Photography) Initialism of optical image stabilization.
PISpis n. Plural of pi.
PIs n. Plural of PI.
PI v. to mix type indiscriminately.
QISqis n. Plural of qi.
QI n. (Chinese) a life force, also KI.
SISsis n. (Informal) Clipping of sister.
sis pron. (AAVE, slang) she.
SIs n. Plural of SI.
TIStis cont. Alternative form of ’tis.
tis n. Plural of ti.
TIs n. Plural of TI.
VISvis n. Force; energy; might; power.
vis n. Abbreviation of viscount.
vis n. Alternative spelling of viss.
WISwis adv. (Rare, obsolete or dialectal) Certainly, surely.
wis adv. (Rare, obsolete or dialectal) Really, truly.
wis adv. (Rare, obsolete or dialectal) Indeed.
XISxis n. Plural of xi.
Xis prop.n. Plural of Xi.
Xis n. Plural of Xi.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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