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There are 5 eight-letter words beginning with SEDAT

SEDATELYsedately adv. Calmly, without excessive emotion or force; in a composed manner.
SEDATE adv. calm, self-possessed.
SEDATESTsedatest adj. Superlative form of sedate: most sedate.
SEDATE adj. calm, self-possessed.
SEDATINGsedating v. Present participle of sedate.
SEDATE v. to tranquillise.
SEDATIONsedation n. The act of sedating, especially by use of sedatives.
SEDATION n. the reduction of stress by sedatives.
SEDATIVEsedative n. (Pharmacology) An agent or drug that sedates, having a calming or soothing effect, or inducing sleep.
sedative adj. (Pharmacology) Calming, soothing, inducing sleep, tranquilizing.
SEDATIVE n. a drug that induces a calm state.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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