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There are 4 six-letter words beginning with SIGNE

SIGNEDsigned adj. Having a signature; endorsed.
signed adj. (Mathematics, computer science) Having both positive and negative varieties.
signed adj. (Of a road, route) Furnished with signs and signposts; signposted.
SIGNEEsignee n. One who signs a contract, especially in athletic contexts.
SIGNEE n. a signer of a document.
SIGNERsigner n. One who signs something.
signer n. One who uses sign language.
SIGNER n. one that signs.
SIGNETsignet n. An object (especially a ring) formerly used to impress a picture into the sealing wax of a document…
SIGNET v. to mark with an official seal.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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