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There are 5 twelve-letter words beginning with SINIS

SINISTERNESSsinisterness n. The state or condition of being sinister.
SINISTERNESS n. the state of being sinister.
SINISTERWISEsinisterwise adj. (Heraldry, archaic) sinister; on the left-hand side from the wearer’s viewpoint.
SINISTERWISE adv. in left-handed fashion.
SINISTRALITYsinistrality n. Left-handedness.
SINISTRALITY n. the state of being sinistral.
SINISTRORSALsinistrorsal adj. Rising spirally from right to left (of the observer); sinistrorse.
SINISTRORSAL adj. of a climbing plant, rising helically and turning to the right.
SINISTROUSLYsinistrously adv. In a sinistrous manner; perversely; wrongly; unluckily.
sinistrously adv. With a tendency to use the left hand.
SINISTROUS adv. inauspicious, sinister, also SINISTER.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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