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There are 17 eight-letter words beginning with SPIR

SPIRACLEspiracle n. A pore or opening used (especially by arthropods and some fish) for respiration.
spiracle n. The blowhole of a whale, dolphin or other similar species.
spiracle n. Any small aperture or vent for air or other fluid.
SPIRAEASspiraeas n. Plural of spiraea.
SPIRAEA n. (Greek) any of a group of plants, including hardhack and meadowsweet, also SPIREA.
SPIRALEDspiraled v. Simple past tense and past participle of spiral.
SPIRAL v. to move in spiral fashion.
SPIRALLYspirally adv. In a spiral fashion.
SPIRAL adv. winding like the thread of a screw.
SPIRANTSspirants n. Plural of spirant.
SPIRANT n. a sound produced by narrowing the air passage.
SPIRATEDspirated adj. Spirally twisted.
SPIRATED adj. spirally twisted.
SPIRELETspirelet n. (Architecture) A small or slender spire.
SPIRELET n. a slender spire.
SPIREMESspiremes n. Plural of spireme.
SPIREME n. a filament forming part of a cell nucleus, also SPIREM.
SPIRIESTSPIRY adj. tall, slender and tapering.
SPIRILLAspirilla n. Plural of spirillum.
SPIRILLUM n. a rigid, spiral-shaped bacterium.
SPIRITEDspirited v. Simple past tense and past participle of spirit.
spirited adj. Lively, vigorous, animated or courageous.
SPIRIT v. to carry off secretly.
SPIRITUSspiritus n. A breathing.
spiritus n. An aspirate.
spiritus n. Any spirituous preparation.
SPIRLINGspirling n. (UK, dialect) sparling.
SPIRLING n. a kind of fish, aka smelt, also SPARLING, SPERLING.
SPIRTINGspirting v. Present participle of spirt.
spirting n. Alternative form of spurting.
SPIRT v. to emit liquid forcibly, also SPURT.
SPIRTLESspirtles v. Third-person singular simple present indicative form of spirtle.
SPIRTLE n. a wooden stick for stirring porridge, also SPURTLE.
SPIRULAESPIRULA n. (Latin) a spiral-shelled mollusk.
SPIRULASspirulas n. Plural of spirula.
SPIRULA n. (Latin) a spiral-shelled mollusk.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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