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There are 16 eight-letter words beginning with SIGN

SIGNABLEsignable adj. That can be signed (represented in sign language).
signable adj. Ready to have a signature affixed to it, as with a contract.
signable adj. Available for the posting of signs.
SIGNAGESsignages n. (Chiefly India) plural of signage.
SIGNAGE n. a system of signs in a community.
SIGNALEDsignaled v. (US, Canada) simple past tense and past participle of signal.
SIGNAL v. to make a sign.
SIGNALERsignaler n. One who signals.
signaler n. A device that sends a signal.
SIGNALER n. (US) one who signals, also SIGNALLER.
SIGNALLYsignally adv. In a signal manner; conspicuously.
SIGNAL adv. notable.
SIGNETEDsigneted adj. Stamped or marked with a signet.
SIGNET v. to mark with an official seal.
SIGNIEURsignieur n. Alternative form of seignior.
SIGNIEUR n. (Shakespeare) a lord, esp. of manor, also SEIGNEUR, SEIGNIOR.
SIGNINGSsignings n. Plural of signing.
SIGNING n. the use of sign language.
SIGNIORISIGNOR n. (Italian) an Italian title of courtesy for a man, also SIGNIOR, SIGNORE.
SIGNIORSsigniors n. Plural of signior.
SIGNIOR n. (Italian) an Italian title of courtesy for a man, also SIGNOR, SIGNORE.
SIGNIORYsigniory n. Alternative form of seigniory.
SIGNIORY n. the power of a seignior, also SEIGNORY, SIGNORIA, SIGNORY.
SIGNLESSsignless adj. Without a sign or signs.
SIGNLESS adj. without signs.
SIGNORASsignoras n. Plural of signora.
SIGNORA n. (Italian) an Italian title of courtesy for a married woman.
SIGNORESSIGNORE n. (Italian) an Italian title of courtesy for a man, also SIGNOR, SIGNIOR.
SIGNORIAsignoria n. Lordship, especially in medieval Italian city states.
SIGNORIA n. (Italian) the governing body of any of various medieval Italian republics, esp. Venice.
SIGNPOSTsignpost n. A post bearing a sign that gives information on directions.
signpost n. (Cryptic crosswords) A word or phrase within a clue that serves as an indicator, rather than being fodder.
signpost v. (Transitive) To install signposts on.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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