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There are 3 eight-letter words beginning with SAFR

SAFRANINsafranin n. A biological stain used in histology and cytology.
SAFRANIN n. the yellow colouring matter in saffron; a coal tar derivative which dyes yellowish red, also SAFRANINE.
SAFROLESsafroles n. Plural of safrole.
SAFROLE n. a colourless oily liquid obtained from sassafras and used in perfumes, soaps etc., also SAFROL.
SAFRONALSAFRONAL n. a spicy-tasting chemical constituent of saffron.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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