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There are 7 eight-letter words beginning with SIS

SISERARYsiserary n. (Obsolete) A severe rebuke or scolding.
siserary n. (Obsolete) A sharp blow.
SISERARY n. a scolding; a blow, also SASARARA, SASSARARA.
SISSIESTsissiest adj. Superlative form of sissy: most sissy.
SISSY adj. effeminate, also CISSY.
SISSYISHsissyish adj. Like a sissy.
SISSYISH adj. resembling a sissy.
SISTEREDsistered v. Simple past tense and past participle of sister.
SISTER v. to treat like a female sibling.
SISTERLYsisterly adj. Of or characteristic of sisters.
sisterly adv. In the manner of a sister, behaving as one would expect of a sister; as a sister, as sisters.
SISTERLY adj. of or resembling a sister.
SISTROIDSISTROID adj. shaped like a sistrum, a kind of rattle.
SISTRUMSsistrums n. Plural of sistrum.
SISTRUM n. (Latin) a kind of rattle, consisting of a wooden or metal frame fitted with loose strips of metal and disks which jingled when moved.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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