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There are 5 five-letter words beginning with SIS

SISALsisal n. A Central American plant, Agave sisalana, cultivated for its sword-shaped leaves that yield fibers used for rope.
sisal n. The fibre of the plant.
sisal n. (Rare) A sisal mat.
SISESsises n. Plural of sis.
SIS n. (short for) sister, also SISS.
SISSYsissy n. (Derogatory, colloquial) An effeminate boy or man.
sissy n. (Derogatory, colloquial) A timid, unassertive or cowardly person.
sissy n. (BDSM) A male crossdresser who adopts feminine behaviours.
SISTAsista n. (AAVE) Pronunciation spelling of sister.
SISTA n. an African-American woman.
SISTSsists n. Plural of sist.
SIST v. to stay, as judicial proceedings; to delay or suspend.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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