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There are 4 fifteen-letter words beginning with SIG

SIGHTLESSNESSESSIGHTLESSNESS n. the state of being sightless.
SIGMOIDECTOMIESsigmoidectomies n. Plural of sigmoidectomy.
SIGMOIDECTOMY n. removal of the sigmoid colon.
SIGMOIDOSCOPIESsigmoidoscopies n. Plural of sigmoidoscopy.
SIGMOIDOSCOPY n. examination of the interior of the rectum and sigmoid colon.
SIGNIFICATIVELYsignificatively adv. In a significative manner.
SIGNIFICATIVE adv. significant, suggestive.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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