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There are 3 twelve-letter words beginning with SOP

SOPHISTICATEsophisticate v. (Transitive).
sophisticate v. (Intransitive) To practise sophistry (“the (deliberate) making of arguments that seem plausible but…
sophisticate n. A person who is sophisticated (“experienced in the ways of the world, that is, cosmopolitan or worldly-wise”)…
SOPHOMORICALsophomorical adj. Sophomoric.
SOPHOMORICAL adj. of or like a sophomore, also SOPHOMORIC.
SOPORIFEROUSsoporiferous adj. (Archaic) soporific, sleep-inducing.
SOPORIFEROUS adj. causing or tending to cause sleep.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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