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There are 15 fifteen-letter words beginning with SI

SIDESPLITTINGLYsidesplittingly adv. In a sidesplitting manner; hilariously.
side-splittingly adv. In a side-splitting way, extremely funnily.
SIDESPLITTING adv. extremely funny.
SIGHTLESSNESSESSIGHTLESSNESS n. the state of being sightless.
SIGMOIDECTOMIESsigmoidectomies n. Plural of sigmoidectomy.
SIGMOIDECTOMY n. removal of the sigmoid colon.
SIGMOIDOSCOPIESsigmoidoscopies n. Plural of sigmoidoscopy.
SIGMOIDOSCOPY n. examination of the interior of the rectum and sigmoid colon.
SIGNIFICATIVELYsignificatively adv. In a significative manner.
SIGNIFICATIVE adv. significant, suggestive.
SILICIFICATIONSsilicifications n. Plural of silicification.
SILICIFICATION n. a process whereby silica replaces the original material of a substance, e.g. wood.
SILVERSMITHINGSSILVERSMITHING n. the craft of the silversmith.
SILVICULTURALLYsilviculturally adv. In terms of, or by means of, silviculture.
SILVICULTURAL adv. relating to silviculture, also SYLVICULTURAL.
SILVICULTURISTSsilviculturists n. Plural of silviculturist.
SILVICULTURIST n. one who practises silviculture, the growing of trees.
SIMPLICIDENTATESIMPLICIDENTATE adj. denoting a member of the Simplicidentata, rodents.
SIMPLIFICATIONSsimplifications n. Plural of simplification.
SIMPLIFICATION n. the act of simplifying.
SINGULARISATIONsingularisation n. Alternative form of singularization.
SINGULARISATION n. the process of singularising, also SINGULARIZATION.
SINGULARIZATIONsingularization n. The process or result of singularizing.
SINGULARIZATION n. the process of singularizing, also SINGULARISATION.
SINISTRODEXTRALsinistrodextral adj. Moving or directed from the left to the right.
SINISTRODEXTRAL adj. going or directed from left to right, as a sinistrodextral script.
SINTERABILITIESsinterabilities n. Plural of sinterability.
SINTERABILITY n. the capacity for being sintered.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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