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There are 5 twelve-letter words beginning with REFRE

REFRESHENERSREFRESHENER n. something that refreshens.
REFRESHENINGrefreshening v. Present participle of refreshen.
REFRESHEN v. to refresh.
REFRESHFULLYrefreshfully adv. In a refreshful manner.
REFRESHFUL adv. (archaic) full of power to refresh.
REFRESHINGLYrefreshingly adv. In a refreshing manner.
REFRESHING adv. REFRESH, to restore the wellbeing and vigour of.
REFRESHMENTSrefreshments n. Plural of refreshment.
REFRESHMENT n. the act of refreshing.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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