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There are 4 eight-letter words beginning with POLYPI

POLYPIDE	• polypide n. The internal contents of a bryozoan; includes the digestive and muscular systems. • POLYPIDE n. a polyp of a colonial animal, also POLYPITE.
POLYPILL	• polypill n. Medication that is a combination drug of multiple active ingredients, and that is intended to be consumed… • POLYPILL n. a proposed pill which has drugs to control cholesterol, blood pressure and clotting.
POLYPINE	• polypine adj. Of or pertaining to a polyp. • POLYPINE adj. of or like a (colonial) polyp.
POLYPITE	• polypite n. (Rare) A fossil polyp. • polypite n. (Rare) An individual polyp of a colonial cnidarian. • POLYPITE n. a polyp of a colonial animal, also POLYPIDE.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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English Wiktionary: 8 words
Scrabble in French: 1 word
Scrabble in Spanish: no word
Scrabble in Italian: no word
Scrabble in German: no word
Scrabble in Romanian: no word

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