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There are 15 twelve-letter words beginning with PROF

PROFANATIONSprofanations n. Plural of profanation.
PROFANATION n. the act or an instance of profaning.
PROFESSIONALprofessional n. A person who belongs to a profession.
professional n. A person who earns their living from a specified activity.
professional n. (Euphemistic) A prostitute.
PROFESSORATEprofessorate n. Professorship.
PROFESSORATE n. the office of a professor.
PROFESSORESSprofessoress n. (Archaic) A female professor.
PROFESSORESS n. a female professor.
PROFESSORIALprofessorial adj. Of, relating to, or characteristic of a professor or professors, or of a professorship or professorships.
PROFESSORIAL adj. of or like a professor.
PROFESSORIATprofessoriat n. Professors in general.
PROFESSORIAT n. the body of college and university teachers at an institution or in society, also PROFESSORIATE.
PROFICIENCESproficiences n. Plural of proficience.
PROFICIENCE n. the state of being proficient, also PROFICIENCY.
PROFICIENTLYproficiently adv. In a proficient manner.
PROFICIENT adv. well advanced in an art, occupation, or branch of knowledge.
PROFITEERINGprofiteering n. The act of making an unreasonable profit not justified by the corresponding assumption of risk, or by…
profiteering v. Present participle of profiteer.
PROFITEERING n. acting as a profiteer.
PROFITEROLESprofiteroles n. Plural of profiterole.
PROFITEROLE n. (French) a small puff of choux pastry, usually filled with cream and covered with a chocolate sauce.
PROFITLESSLYprofitlessly adv. In a profitless manner.
PROFITLESS adv. without profit.
PROFLIGACIESprofligacies n. Plural of profligacy.
PROFLIGACY n. the state of being profligate.
PROFLIGATELYprofligately adv. In a profligate manner.
PROFLIGATE adv. debauched; rashly extravagant.
PROFOUNDNESSprofoundness n. The quality of being profound; profundity.
PROFOUNDNESS n. the state of being profound.
PROFUNDITIESprofundities n. Plural of profundity.
PROFUNDITY n. intellectual depth.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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