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There are 5 ten-letter words beginning with PEST

PESTERMENTpesterment n. The act of pestering, or the state of being pestered; vexation; worry.
PESTERMENT n. the act of pestering, or the state of being pestered.
PESTHOUSESpesthouses n. Plural of pesthouse.
PESTHOUSE n. (historical) a house or hospital for persons who are infected with any pestilential disease.
PESTICIDALpesticidal adj. Of, pertaining to, or effective as a pesticide.
PESTICIDAL adj. of or like a pesticide.
PESTICIDESpesticides n. Plural of pesticide.
PESTICIDE n. a substance for killing pests.
PESTILENCEpestilence n. Any epidemic disease that is highly contagious, infectious, virulent and devastating.
pestilence n. (Archaic) Anything harmful to morals or public order.
Pestilence prop.n. The personification of pestilence, often depicted riding a white horse.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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