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There are 13 six-letter words beginning with PIS

PISCOSpiscos n. Plural of pisco.
PISCO n. a Peruvian brandy.
PISHEDpished v. Simple past tense and past participle of pish.
PISH v. to express contempt.
PISHERpisher n. (Derogatory) Somebody who is inept at a task or new to a job.
pisher n. (Informal) A young child, usually male.
PISHER n. (Yiddish) a small boy; a young, inexperienced person.
PISHESpishes v. Third-person singular simple present indicative form of pish.
PISH v. to express contempt.
PISSEDpissed v. Simple past tense and past participle of piss.
pissed adj. (UK, Ireland, Australia, New Zealand, South Africa, Canada, colloquial) Drunk.
pissed adj. (US, Canada, mildly vulgar, colloquial) Annoyed, angry.
PISSERpisser n. (Mildly vulgar) One who pisses.
pisser n. (Mildly vulgar) That which pisses, particularly a penis.
pisser n. (US dialect, slang, mildly vulgar) Someone or something impressive or remarkable.
PISSESpisses n. Plural of piss.
pisses v. Third-person singular simple present indicative form of piss.
PISS v. to urinate.
PISTEDPISTED adj. marked off into pistes.
PISTESpistes n. Plural of piste.
PISTE n. (French) a ski-trail.
PISTILpistil n. (Botany) A discrete organ in the center of a flower capable of receiving pollen and producing a fruit…
PISTIL n. the seed-bearing organ of flowering plants.
PISTOLpistol n. A handgun.
pistol n. The mechanical component of a fuse in a bomb or torpedo responsible for firing the detonator.
pistol n. A creative and unpredictable jokester, a constant source of entertainment and surprises.
PISTONpiston n. A solid disk or cylinder that fits inside a hollow cylinder, and moves under pressure (as in an engine)…
piston n. (Music) A valve device in some brass instruments for changing the pitch.
piston v. (Intransitive) To move up and down or in and out like a piston.
PISTOUpistou n. A cold sauce made from cloves of garlic, fresh basil, and olive oil.
PISTOU n. (French) a French sauce made of olive oil, garlic, basil, and often cheese.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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