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There are 5 eight-letter words beginning with OPPO

OPPONENS	• OPPONENS n. a muscle of the thumb.
OPPONENT	• opponent n. One who opposes another; one who works or takes a position against someone or something; one who attempts… • opponent adj. (Obsolete) Opposing; adverse; antagonistic. • opponent adj. (Obsolete) Situated in front; opposite.
OPPOSERS	• opposers n. Plural of opposer. • OPPOSER n. one who opposes.
OPPOSING	• opposing adj. That opposes or oppose; on the opposite side. • opposing v. Present participle of oppose. • OPPOSE v. to conflict with.
OPPOSITE	• opposite adj. Located directly across from something else, or from each other. • opposite adj. (Botany) Of leaves and flowers, positioned directly across from each other on a stem. • opposite adj. Facing in the other direction.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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See this list for:

English Wiktionary: 11 words
Scrabble in French: 10 words
Scrabble in Spanish: no word
Scrabble in Italian: 9 words
Scrabble in German: 3 words
Scrabble in Romanian: no word

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1word.ws to play with words, anagrams, suffixes, prefixes, etc.
Ortograf.ws to look for words.

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