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There are 5 six-letter words beginning with OPTI

OPTICS	• optics n. (Physics) The physics of light and vision. • optics n. The light-related aspects of a device. • optics n. (Figuratively) Perception, image, public relations, especially in politics.
OPTIMA	• optima n. Plural of optimum. • OPTIMUM n. (Latin) the most favourable point of any condition.
OPTIME	• optime n. (Cambridge University) A student who graduates with second class ("senior optime") or third class ("junior… • OPTIME n. (Latin) an honour student in mathematics at Cambridge University.
OPTING	• opting v. Present participle of opt. • OPT v. to decide or choose.
OPTION	• option n. One of a set of choices that can be made. • option n. The freedom or right to choose. • option n. (Finance, law) A contract giving the holder the right to buy or sell an asset at a set strike price;…

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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English Wiktionary: 6 words
Scrabble in French: 3 words
Scrabble in Spanish: 5 words
Scrabble in Italian: 2 words
Scrabble in German: 3 words
Scrabble in Romanian: 6 words

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