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There are 10 eight-letter words beginning with OSS

OSSARIUMossarium n. An ossuary.
OSSARIUM n. (Latin) a depository for the bones of the dead, also OSSUARY.
OSSATUREossature n. A skeletal framework; an underlying structure.
ossature n. (Architecture) Any supporting framework under a vault, roof etc.
OSSATURE n. a skeleton.
OSSELETSosselets n. Plural of osselet.
OSSELET n. a hard substance growing on the inside of a horse's knee.
OSSETERSosseters n. Plural of osseter.
OSSETER n. (Russian) a species of sturgeon.
OSSETRASOSSETRA n. (Russian) a type of caviar, also OSETRA.
OSSICLESossicles n. Plural of ossicle.
OSSICLE n. a small bone.
OSSIFIEDossified adj. Having undergone the process of ossification (transformation into bone).
ossified adj. (Figurative) Inflexible, old-fashioned.
ossified adj. (Ireland, US, slang) Drunk.
OSSIFIERossifier n. One who, or that which, ossifies.
OSSIFIER n. an agent that causes ossification.
OSSIFIESossifies v. Third-person singular simple present indicative form of ossify.
OSSIFY v. to change into bone; to become callous or conventional.
OSSOBUCOossobuco n. Alternative spelling of osso buco.
osso␣buco n. A northern Italian dish of veal shanks and marrowbones braised in white wine, tomatoes, etc., often…
OSSOBUCO n. (Italian) an Italian dish of veal knuckle cooked with the bone and stewed in wine, herbs etc.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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