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There are 2 seven-letter words beginning with OPO

OPORICEoporice n. (Obsolete) A medicine prepared from quinces, pomegranates, etc.
OPORICE n. (Greek) an old medicine made from summer fruits.
OPOSSUMopossum n. Any American marsupial of the family Didelphidae. The common species of the United States is Didelphis virginiana.
OPOSSUM n. (Native American) any of various small or medium-sized marsupial mammals, mostly arboreal.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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