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There are 5 six-letter words beginning with OPI

OPIATEopiate adj. Relating to, resembling, or containing opium.
opiate adj. (Pharmacology) Soporific; inducing sleep or sedation.
opiate adj. Deadening; causing apathy or dullness.
OPINEDopined v. Simple past tense and past participle of opine.
OPINE v. to hold as an opinion.
OPINESopines v. Third-person singular simple present indicative form of opine.
OPINE v. to hold as an opinion.
OPIOIDopioid n. A substance that has effects similar to opium.
opioid n. (Physiology) Any of the natural substances, such as an endorphin, released in the body in response to pain.
opioid n. (Pharmacology) Any of a group of synthetic compounds that exhibit similarities to the opium alkaloids…
OPIUMSopiums n. Plural of opium.
OPIUM n. an addictive narcotic.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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