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There are 3 five-letter words beginning with OPE

OPENSopens n. Plural of open.
opens v. Third-person singular simple present indicative form of open.
OPEN v. to cause to become open.
OPEPEopepe n. Synonym of bilinga (tropical hardwood).
OPEPE n. (Yoruba) a West African tree yielding a hard yellowish wood used as a substitute for teak.
OPERAopera n. (Music) A theatrical work, combining drama, music, song and sometimes dance.
opera n. (Music) The score for such a work.
opera n. A building designed for the performance of such works; an opera house.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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