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There is only one ten-letter word beginning with MELANC

MELANCHOLYmelancholy n. (Historical) Black bile, formerly thought to be one of the four "cardinal humours" of animal bodies.
melancholy n. Great sadness or depression, especially of a thoughtful or introspective nature.
melancholy adj. (Literary) Affected with great sadness or depression.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org.

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