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There are 2 eight-letter words beginning with MASTO

MASTODONmastodon n. Extinct elephant-like mammal of the genus Mammut that flourished worldwide from Miocene through Pleistocene…
mastodon n. (Figurative) Anything big or clunky.
Mastodon prop.n. (Social media) A decentralized microblogging platform, part of the Fediverse.
MASTOIDSmastoids n. Plural of mastoid.
MASTOID n. a prominence on the temporal bone behind the ear.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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