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There are 3 eight-letter words beginning with MESC

MESCALINmescalin n. Alternative form of mescaline.
MESCALIN n. the principal alkaloid in mescal, used as a hallucinogen, also MESCALINE, MEZCALINE.
MESCLUMSMESCLUM n. (French) a mixed salad of young leaves and shoots, e.g. of rocket, chicory, fennel etc., also MESCLUN.
MESCLUNSmescluns n. Plural of mesclun.
MESCLUN n. (French) a mixed salad of young leaves and shoots, e.g. of rocket, chicory, fennel etc., also MESCLUM.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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