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There are 4 six-letter words beginning with MAIN

MAINEDmained v. Simple past tense and past participle of main.
MAIN v. to maim or cripple.
MAINERmainer n. (US slang) A needle for (illicit) drug administration.
Mainer n. A native or resident of the state of Maine in the United States of America.
Mainer prop.n. A surname transferred from the given name.
MAINLYmainly adv. Chiefly; for the most part.
mainly adv. (Obsolete) Forcefully, vigorously.
mainly adv. (Obsolete) Of the production of a sound: loudly, powerfully.
MAINORmainor n. (Law, UK, obsolete) The act or fact, especially of theft.
mainor n. (Law, UK, obsolete) A stolen article found on the person of the thief.
Mainor prop.n. A surname.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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