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There is only one four-letter word beginning with LOCO

LOCOloco adv. (Music) A direction in written or printed music to be returning to the proper pitch after having played…
loco adj. (Colloquial) Crazy.
loco adj. (Southwestern US) Intoxicated by eating locoweed.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org.

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