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There are 5 six-letter words beginning with LUP

LUPINElupine adj. Of, or pertaining to, the wolf.
lupine adj. Wolflike; wolfish.
lupine adj. Having the characteristics of a wolf.
LUPINSlupins n. Plural of lupin.
LUPIN n. any papilionaceous plant of the genus Lupinus, also LUPINE.
LUPOIDlupoid adj. Resembling the disease called lupus.
LUPOID adj. suffering from lupus.
LUPOUSlupous adj. Affected with or pertaining to lupus.
LUPOUS adj. pertaining to lupus, a skin disease.
LUPPENLEAP v. (Scots) to spring off the ground.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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