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There are 2 six-letter words beginning with INFAM

INFAMEinfame v. (Transitive, obsolete) To defame; to make infamous.
INFAME v. (archaic) to defame.
INFAMYinfamy n. The state of being infamous.
infamy n. A reprehensible occurrence or situation.
infamy n. (Law) A stigma attaching to a person’s character that disqualifies them from being a witness.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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