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There are 2 eight-letter words beginning with IST

ISTHMIANisthmian adj. Of or pertaining to an isthmus, especially to the Isthmus of Corinth, in Greece.
isthmian n. A native or inhabitant of an isthmus.
Isthmian adj. Of or from the Isthmus of Corinth.
ISTHMOIDisthmoid n. (Graph theory) A set of vertices of a graph after whose deletion the graph is no longer connected.
ISTHMOID adj. pertaining to an isthmus, also ISTHMIC.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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