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There are 6 eight-letter words beginning with ISA

ISABELLAisabella n. A pale grey-yellow, fawn, cream-brown or parchment colour.
Isabella prop.n. A female given name from Hebrew.
Isabella n. A grape a cultivar popular in the former USSR derived from the grape species Vitis labrusca.
ISAGOGESisagoges n. Plural of isagoge.
ISAGOGE n. (Greek) an academic introduction to a subject.
ISAGOGICisagogic adj. (Chiefly theology) introductory.
ISAGOGIC adj. introductory.
ISARITHMisarithm n. An isoline, or contour line.
ISARITHM n. a line on a map passing through places of the same density of population.
ISATINESisatines n. Plural of isatine.
ISATINE n. a substance obtained by oxidising indigo, also ISATIN.
ISATINICisatinic adj. Relating to isatin.
ISATINIC adj. pertaining to, or derived from, isatin, a substance obtained by oxidising indigo.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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