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There are 6 eight-letter words beginning with IRR

IRRIGATEirrigate v. (Transitive) To supply (farmland) with water, by building ditches, pipes, etc.
irrigate v. (Transitive) To clean (a wound) with a fluid.
IRRIGATE v. to water by canals or watercourses.
IRRISIONirrision n. (Obsolete) The act of laughing at another; derision.
IRRISION n. the act of laughing at another.
IRRISORYirrisory adj. Expressing irrision; mocking.
IRRISORY adj. mocking.
IRRITANTirritant adj. Causing irritation or inflammation.
irritant adj. (Law, Scotland) Rendering null and void; conditionally invalidating.
irritant n. Any medication designed to cause irritation.
IRRITATEirritate v. (Transitive) To provoke impatience, anger, or displeasure in.
irritate v. (Intransitive) To cause or induce displeasure or irritation.
irritate v. (Transitive) To induce pain in (all or part of a body or organism).
IRRUPTEDirrupted v. Simple past tense and past participle of irrupt.
IRRUPT v. to enter forcibly or violently.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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