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There are 3 seven-letter words beginning with IST

ISTANASISTANA n. (Malay) in Malaysia, a royal palace.
ISTHMICisthmic adj. (Anatomy) Relating to an (anatomical) isthmus.
ISTHMIC adj. pertaining to an isthmus, also ISTHMOID.
ISTHMUSisthmus n. A narrow strip of land, bordered on both sides by water, and connecting two larger landmasses.
isthmus n. (Anatomy) Any such narrow part connecting two larger structures.
isthmus n. (Graph theory) An edge in a graph whose deletion increases the number of connected components of the graph.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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