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There are 20 six-letter words beginning with INS

INSANEinsane adj. Exhibiting unsoundness or disorder of mind; not sane; utterly mad.
insane adj. Used by or relating to insane people.
insane adj. Causing insanity or madness.
INSEAMinseam n. The seam of a trouser up the inside of the leg.
inseam v. (Transitive) To fit (trousers) with an inseam.
inseam v. (Transitive) To impress or mark with a seam or cicatrix.
INSECTinsect n. An arthropod (in the Insecta class) characterized by six legs, up to four wings, and a chitinous exoskeleton.
insect n. (Colloquial) Any small arthropod similar to an insect, including spiders, centipedes, millipedes, etc.
insect n. (Derogatory) A contemptible or powerless person.
INSEEMINSEEM v. (Shakespeare) to grease, defile, also ENSEAM, INSEAM.
INSERTinsert v. (Transitive) To put in between or into.
insert n. An image inserted into text.
insert n. A promotional or instructive leaflet inserted into a magazine, newspaper, tape or disk package, etc.
INSETSinsets n. Plural of inset.
insets v. Third-person singular simple present indicative form of inset.
INSET v. to set in, in fix.
INSHIPinship v. (Transitive, dated) To put aboard a ship.
inship v. (Transitive) Alternative form of enship (“to travel or send by ship”).
inship v. (Transitive) To ship in from abroad; to import.
INSIDEinside n. The interior or inner part.
inside n. The left-hand side of a road if one drives on the left, or right-hand side if one drives on the right.
inside n. The side of a curved road, racetrack etc. that has the shorter arc length; the side of a racetrack nearer…
INSISTinsist v. (With on or upon or (that + ordinary verb form)) To hold up a claim emphatically.
insist v. (Sometimes with on or upon or (that + subjunctive)) To demand continually that something happen or be…
insist v. (Obsolete, chiefly geometry) To stand (on); to rest (upon); to lean (upon).
INSOLEinsole n. The inside sole of a shoe or other footwear.
insole v. (Transitive) To fit (footwear) with an insole.
INSOLE n. the inner sole of a shoe or boot.
INSOULinsoul v. (Obsolete) To set a soul in; reflexively, to fix one’s strongest affections on.
INSOUL v. to infuse with a soul, also ENSOUL.
INSPANinspan v. (Transitive) To yoke (oxen).
inspan v. To bring or force into service.
INSPAN v. (South African) to harness or yoke animals to a vehicle.
INSPOSINSPO n. someone or something that is a source of inspiration.
INSTALinstal v. (Transitive, dated) Alternative spelling of install.
instal v. (Britain, rare) To pay by instalments.
INSTAL v. to place in position for use, also INSTALL.
INSTARinstar n. Any one of the several stages of postembryonic development which an arthropod undergoes, between molts…
instar n. An arthropod at a specified one of these stages of development.
instar n. (By extension) A stage in development.
INSTEPinstep n. (Anatomy) The arched part of the top of the foot between the toes and the ankle.
instep n. A section of any footwear covering that part of the foot.
instep n. In horses, the hind leg from the ham to the pastern joint.
INSTILinstil v. Australia, Ireland, and UK standard spelling of instill.
INSTIL v. to infuse slowly, also INSTILL.
INSULAinsula n. (Historical) A block of buildings in a Roman town.
insula n. (Neuroanatomy) A structure of the human brain located within the lateral sulcus.
INSULA n. (Latin) a Roman block of buildings.
INSULTinsult v. (Transitive) To be insensitive, insolent, or rude to (somebody); to affront or demean (someone).
insult v. (Transitive, also figuratively, obsolete) To assail, assault, or attack; (specifically, military) to…
insult v. (Intransitive, obsolete) To behave in an obnoxious and superior manner (against or over someone).
INSUREinsure v. (Transitive) To provide for compensation if some specified risk occurs. Often agreed by policy (contract)…
insure v. (Intransitive) To deal in such contracts; subscribe to a policy of insurance.
insure v. (Chiefly US, transitive, dated) Alternative spelling of ensure; to make sure or certain of; guarantee.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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