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There are 2 three-letter words beginning with IR

IREire n. (Obsolete) Iron.
ire n. Great anger; wrath; keen resentment.
ire v. (Transitive, rare) To anger, to irritate.
IRKirk v. (Transitive) to irritate; annoy; bother.
Irk prop.n. A river in Greater Manchester, England, which joins the River Irwell in Manchester city centre.
IRK v. to annoy or weary.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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