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There are 5 words beginning with INSIGNIFICAN

INSIGNIFICANT	• insignificant adj. Not significant; not important, inconsequential, or having no noticeable effect. • insignificant adj. Without meaning; not signifying anything. • INSIGNIFICANT adj. not significant.
INSIGNIFICANCE	• insignificance n. The state of being insignificant. • INSIGNIFICANCE n. the state of being insignificant, also INSIGNIFICANCY.
INSIGNIFICANCY	• insignificancy n. (Obsolete) Lack of signification; meaninglessness. • insignificancy n. Unimportance, insignificance. • insignificancy n. An insignificant person or thing.
INSIGNIFICANCES	• insignificances n. Plural of insignificance. • INSIGNIFICANCE n. the state of being insignificant, also INSIGNIFICANCY.
INSIGNIFICANTLY	• insignificantly adv. In an insignificant manner, or to a degree that does not matter. • INSIGNIFICANT adv. not significant.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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English Wiktionary: 6 words
Scrabble in French: no word
Scrabble in Spanish: 3 words
Scrabble in Italian: 4 words
Scrabble in German: no word
Scrabble in Romanian: no word

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