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There are 3 eight-letter words beginning with HISTO

HISTOGENhistogen n. (Biology) Any of the germ layers involved in histogenesis.
HISTOGEN n. a more or less well-defined region within a plant where tissues undergo differentiation.
HISTONEShistones n. Plural of histone.
HISTONE n. any of a group of simple proteins present in chromosomes and believed to act as gene inhibitors.
HISTORIChistoric adj. Very important; noteworthy: having importance or significance in history.
historic adj. Old-fashioned, untouched by modernity.
historic adj. (Now uncommon) Synonym of historical: of, concerning, or in accordance with recorded history or the…

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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