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There are 10 eight-letter words beginning with HIS

HISSIESThissiest adj. Superlative form of hissy: most hissy.
HISSY adj. temperamental.
HISSINGShissings n. Plural of hissing.
HISSING n. an object of scorn.
HISTAMINhistamin n. Dated form of histamine.
HISTAMIN n. a base used in medicine obtained from ergot and present in all the tissues of the body, also HISTAMINE.
HISTIDINhistidin n. Dated form of histidine.
HISTIDIN n. an amino acid found in proteins, also HISTIDINE.
HISTIOIDhistioid adj. Synonym of histoid.
HISTIOID adj. resembling the normal tissues; as, histioid tumors, also HISTOID.
HISTOGENhistogen n. (Biology) Any of the germ layers involved in histogenesis.
HISTOGEN n. a more or less well-defined region within a plant where tissues undergo differentiation.
HISTONEShistones n. Plural of histone.
HISTONE n. any of a group of simple proteins present in chromosomes and believed to act as gene inhibitors.
HISTORIChistoric adj. Very important; noteworthy: having importance or significance in history.
historic adj. Old-fashioned, untouched by modernity.
historic adj. (Now uncommon) Synonym of historical: of, concerning, or in accordance with recorded history or the…
HISTRIONhistrion n. (Obsolete) A stage actor.
HISTRION n. (archaic) an actor, also HISTRIO.
HISTRIOSHISTRIO n. (archaic) an actor, also HISTRION.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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